Poly(amidoamine) Dendrimers Increase Antifungal Activity of Clotrimazole
نویسندگان
چکیده
منابع مشابه
In vitro antifungal activity of clotrimazole (Bay b 5097).
The in vitro antifungal activity of clotrimazole (Bay b 5097) was compared with those of amphotericin B, griseofulvin, nystatin, and pyrrolnitrin. The inhibitory activity of clotrimazole against most systemic pathogens was comparable to that of amphotericin B; minimal inhibitory concentrations of the two drugs for Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococ...
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Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH(2) and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evalu...
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The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. Experimental analysis of these glycosylated dendrimers showed that, on average, eight glucosamine molecules were covalently bound to each dendrimer. In order to better understa...
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OBJECTIVE In this study the mechanism of interactions between polyamidoamine (PAMAM) dendrimers and bovine insulin was examined. The insulin is a 51 amino acid peptide-hormone involved in the homeostasis of blood glucose levels. This molecule consists of two chains - A and B - linked by two disulphide bridges. As insulin contains four tyrosine residues it was possible to evaluate dendrimers eff...
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The efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading c...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2011
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.34.1129